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Multivariate logistic regression revealed the following factors predicting outcome (inability to walk independently) at 8 weeks: a preceding gastrointestinal illness (yes,no), age (>/=50, <50 years). Medical Research Council sum score (<40 , >/=40) at the start of treatment, and - described for the first time -a recent cytomegalovirus (CMV) infection (yes, no). At 6 months, the same clinical factors were found, but an initial rapid progression of weakness also appeared to be a prognostic f actor. Analysis of treatment interactions revealed that the effect of diarrhea was more pronounced in the PE-treated group. The main predictors of outcome in GBS are clinical factors. Diarrhea is an important poor predictor of outcome, especially for t he PE-treated group, and a recent CMV infection predicts delayed early recovery. |
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